16 March 2025
Read the latest research on human biology. Learn about comparative biology and human genetics.
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Scientists discover how to reactivate cancer's molecular 'kill switch'
Researchers have discovered that cancer cells suppress 'poison exons' -- genetic elements that act as an off switch for protein production -- in a key gene called TRA2 , promoting tumor growth. By using antisense oligonucleotides (ASOs) to restore poison exon activity, the team effectively reactivated this kill switch, offering a potential new precision therapy for aggressive, hard-to-treat cancers.
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Cellular circuit controls how DNA damage is repaired, affecting risk of disease as we age
New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like cells to spew inflammatory molecules that can contribute to chronic inflammation in the body.
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Scientists solve decades-long Parkinson's mystery
Researchers have made a huge leap forward in the fight against Parkinson's disease, solving a decades-long mystery. In a major breakthrough, they have been able to see the human PINK1 protein and how it is switched on for the first time. The discovery is a significant milestone in Parkinson's research that paves the way for developing new life-changing drugs.
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Antigenic variation: Decoding the mechanism controlling antigen activation in trypanosomes
A new study shows how pathogens control changes in their cell surface to evade the immune system.
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RNA molecule identified as possible driver of gastric cancer
Researchers have discovered molecules that present the potential to drive the development of gastric cancer.
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New CRISPRs expand upon the original's abilities
Researchers have discovered a handful of new CRISPR-Cas systems that could add to the capabilities of the already transformational gene editing and DNA manipulation toolbox. Of the new recruits, one system from bacteria commonly found in dairy cows shows particular promise for human health.
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New method uses DNA barcodes for high throughput RNA and protein detection in deep tissue
An innovative new technique uses a novel DNA barcode system to track hundreds of RNA and protein molecules in single cells within thick biological samples, providing researchers with a full picture of how these structures are organized inside tissues.
